Introduction Le syndrome d’hypersensibilité médicamenteuse ou DRESS (Drug Rash with Eosinophilia and Systemic symptoms) est une entité nouvellement. Annales françaises d’anesthésie et de réanimation – Vol. 32 – N° 6 – p. – Iconography: Ictère fébrile et si c’était une leptospirose. À propos d’un cas de. pour là première fois constatée nettement, à la suite d’un embarras gastrique fébrile. Depuis lors, l’ictère a été permanent, quoique variable dans son intensité .

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Son diagnostic est difficile en raison du polymorphisme clinique. Leptospirosis is an anthropozoonose, icttere animal disease transmissible to humans, caused by a spirochete of the genus Leptospira that lives mainly among rodents but also in wetlands. It occurs worldwide, particularly in Asia, Latin America and Africa. In Europe, the incidence is small except in France and Great Britain, where its frequency has increased in recent years but the frequency may be underestimated. Some areas overseas are particularly affected.

In France, the potential epidemic of leptospirosis is subject to climatic variations, justifying a constant monitoring of the disease provided by the National Reference Centre CNR of leptospires. Transmission to humans primarily occurs through contact with environments contaminated by the urine of infected animals. The disease can affect cebrile liver and kidneys hepatonephritis as cytolysis, cholestasis and renal failure associated with fever.


A coagulopathy usually accompanies the clinical table. Its diagnosis is difficult because of the clinical polymorphism. Early diagnosis of leptospirosis allows effective medical care, improving patient outcomes.

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This is currently based on gene amplification PCR or serology positive by the microscopic agglutination test MATwhich is the reference method. Its evolution is usually favorable with appropriate antibiotic treatment aminopenicillin. Nearly a century after the discovery of the causative agent, this zoonosis remains icteree public health problem, zoonosis priority in terms of virulence, its reporting is mandatory in our country. We report the case of a severe form of hepatonephritis due to water contaminated with Leptospira observed in Northern France.

FÉBRILE – Definition and synonyms of fébrile in the French dictionary

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