This resource may include information that has not been approved by the US Food and Drug Administration. For full prescribing information, including. Fosphenytoin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Medscape – Epilepsy dosing for Cerebyx (fosphenytoin), frequency-based adverse contraindications, pregnancy & lactation schedules, and cost information. be expressed as phenytoin sodium equivalents (PE) when prescribing; There is.

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Carboplatin Carboplatin can pfescribing a decrease in the absorption of Fosphenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy.

John’s wort can alter their phenytoin levels. Etifoxine The risk or severity of adverse effects can be invormation when Fosphenytoin is combined with Etifoxine. However, this list is not intended to be inclusive or comprehensive.

Pro-Epanutin is intended for short-term parenteral administration, and has not been evaluated for periods of more than 5 days. Bryostatin 1 The metabolism of Fosphenytoin can be decreased when combined with Bryostatin 1.

Cimicifuga racemosa The metabolism of Fosphenytoin can be decreased when combined with Cimicifuga racemosa. Concurrent adverse events or clinical laboratory change suggesting an allergic process were not seen [see Warnings and Precautions 5. Doxifluridine The serum concentration of Fosphenytoin can be increased when it is combined with Doxifluridine. Continue typing to refine. This study also demonstrated that equimolar doses of IM Fosphenytoin Sodium Injection may be substituted for oral phenytoin sodium with no dosage adjustments needed when initiating IM or returning to oral therapy.

Infliximab The metabolism fosphenytoib Fosphenytoin can be increased when combined with Infliximab. Dasatinib The metabolism of Dasatinib can be increased when combined with Fosphenytoin.

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Fosphenytoin – DrugBank

Fertility In animal studies, fosphenytoin had no effect on fertility in male rats but decreased fertility in female rats see section 5. Dexfenfluramine The metabolism of Dexfenfluramine can be increased when combined with Fosphenytoin. Method of administration Pro-Epanutin may be administered by intravenous IV infusion or by intramuscular IM injection.

Dexrabeprazole The metabolism of Dexrabeprazole can be decreased when combined with Fosphenytoin. Gliquidone The metabolism of Fosphenytoin can be decreased when combined with Gliquidone. Dapiprazole The risk or severity of adverse effects can be increased when Dapiprazole is combined with Fosphenytoin. Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Fosphenytoin. Flurbiprofen The metabolism of Fosphenytoin can be decreased when combined with Flurbiprofen.

Serious Dermatologic Reactions Advise patients of the early signs and symptoms of severe cutaneous adverse reactions and to report any occurrence immediately to a physician [ see Warnings and Precautions 5.

Throughout all Pro-Epanutin product labelling, the amount and concentration of fosphenytoin is always expressed in terms of phenytoin sodium equivalents PE to avoid the need to perform molecular weight-based adjustments when converting between fosphenytoin and phenytoin sodium doses. Plasma phenytoin concentrations should be determined at the first sign of acute toxicity see section 4. Glycerol phenylbutyrate The metabolism of Fosphenytoin can be increased when combined with Glycerol phenylbutyrate.

Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Fosphenytoin. Gaboxadol The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Gaboxadol. Table 3 includes commonly occurring drug interactions that affect phenytoin the active metabolite of Fosphenytoin Sodium Injection concentrations.

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Fosphenytoin

Cases of acute hepatotoxicity, including infrequent cases of acute hepatic failure, have been reported with phenytoin the active metabolite of CEREBYX. Prenatal exposure to phenytoin the active metabolite of CEREBYX may increase the risks for congenital malformations and other adverse developmental outcomes [see Use in Specific Populations 8.

Bendamustine The metabolism of Bendamustine can be increased when combined with Fosphenytoin. Volker Kirsch, “Process for the preparation of sodium fosphenytoin.

Sulfamethizole, sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim. Grepafloxacin The metabolism of Fosphenytoin can be decreased when combined with Grepafloxacin.

FOSPHENYTOIN SODIUM Injection mg PE in 2ml Vial mg PE in 10 ml Vial | Mylan

Company contact details Pfizer Limited. Lercanidipine The metabolism of Fosphenytoin can be decreased when combined with Lercanidipine. Darifenacin The metabolism of Darifenacin can be increased when combined with Fosphenytoin.

Decamethonium The therapeutic efficacy of Decamethonium can be decreased when used in combination with Fosphenytoin. Cyclobenzaprine The metabolism of Cyclobenzaprine can be increased when combined with Fosphenytoin. Fosphenytoin had no effect on fertility in male rats. Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Fosphenytoin.

This may or may not be associated with extravasation. Dalfopristin The metabolism of Fosphenytoin can be decreased when combined with Dalfopristin.

These errors have resulted in two- or ten-fold overdoses of Fosphenytoin Sodium Injection since each vial actually contains a total of mg PE or mg PE.