mato es una causa poco conocida de acidosis metabólica con anión restante normal; al inhibir la anhidrasa carbónica, se ocasiona una acido- sis tubular renal. therefore raised as to the level of the enzyme in the kidneys of premature infants. If the . La Anhidrasa Carbonica Renal en Prematuros y Niiios a Termino. Acidosis tubular renal inducida por topiramato. por su efecto inhibidor de la anhidrasa carbónica (renal y la localizada en neuroglía, mielina y plexo coroideo ).

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The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal carboncia and external reviews.

The journal accepts submissions of articles in English and in Spanish languages. The Impact Factor measures the carbonnica number of citations received in a particular year by papers published in the journal during anhodrasa two receding years.

CiteScore measures average citations received per document published. SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact. SNIP measures anhidgasa citation impact by wighting citations based on the total number of citations in a subject field. Topiramate is an antiepileptic drug also used to treat bipolar disorder, neuropathic pain and migraine.


The potential side effects of the drug include metabolic acidosis due to renal bicarbonate loss and the accumulation of CO2 in the brain, as a result of its inhibitory action upon carbonic anhydrase renal and located in the microglia, myelin and choroid plexus. The Service of Nephrology was consulted due to the sustained presence of acidosis.

The complementary explorations revealed the following: The complete blood count and baseline coagulation parameters were normal. The studies of hypercoagulability and autoimmunity proved negative. Twenty-four hour urine showed: The urine sediment was normal. The echo-Doppler findings in the lower extremities were compatible with DVT, and computed tomographic angiography showed signs typical of bilateral PTE.

Polysomnography revealed episodes of hypopnea and hypoventilation, without apnea.

The observed pattern was not suggestive of obstructive sleep apnea syndrome OSAS. The evolution of the blood gas parameters was as follows: The GAP anion was normal in all cases between With anticoagulation, the PTE tended to resolve. A renal biopsy was discarded, and stage III CKF secondary to diminished nephron mass and probable chronic interstitial nephropathy was diagnosed.

Carbonic anhydrase

BiPAP corrected the respiratory component of acidosis associated to central hypopnea, although GAP anion-normal hyperchloremic metabolic acidosis persisted. On administering bicarbonate, the tendency towards acidosis persisted, though to a lesser degree, and the pH was corrected upon carboniac topiramate. We recommend to the monitorization of serum bicarbonate during topiramate treatment, particularly in patients with respiratory problems or renal failure.

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Carbonic anhydrase inhibitor – Wikipedia

Previous article Next article. December Pages Acidosis tubular renal inducida por topiramato. This item has received. The potential rdnal effects of the drug include metabolic acidosis due to renal bicarbonate loss and the accumulation of CO2 in the brain, as a result of its inhibitory action upon carbonic anhydrase renal and located in the microglia, myelin and choroid plexus.


An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action. Topiramate and metabolic acidosis. Topiramate induced metabolic acidosis. Topiramate and metabolic acidosis: Pediatric Anesthesia ; 15 2??

Carbonic anhydrase inhibitor

Topiramate-induced renal tubular acidosis. Am J Med ; Predisposition to metabolic acidosis induced by cabronica. Topiramate and severe metabolic acidosis: Topiramate as an inhibitor of carbonic anhydrase isoenzymes.

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