A Handbook of Bioanalysis and Drug Metabolism. Front Cover. Gary Evans. CRC Press, Mar 29, – Medical – pages. A Handbook of Bioanalysis and Drug Metabolism is an invaluable guide to senior undergraduates and postgraduates studying drug metabolism in courses such. Download Citation on ResearchGate | On Nov 1, , Manfred E. Wolff and others published A Handbook of Bioanalysis and Drug Metabolism Edited by Gary.
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A Handbook of Bioanalysis and Drug Metabolism is a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. Account Options Sign in. Shopbop Designer Fashion Brands. Remember me on this computer. The quality of information is of a level suitable for scientific evaluation and decision- making.
Good text with a nice q of chapters. Get to Know Us. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. In drug development, a single compound is progressed and information relating to the safety of the drug and the dosage required for efficacy in man is obtained. The detector of choice is a mass spectrometer.
Already read this title? The scientists conducting these functions metbaolism be geographically separated or, increas- ingly, scientists may specialise in one of the functional areas. Product pricing will be adjusted to match the corresponding currency.
The major routes of metabolism and the enzyme systems involved are well documented although it is an area under continuing development, particularly the Phase 2 enzyme systems. However, the functions are closely inter-related and may be considered a single scientific discipline.
This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.
My library Help Advanced Book Search. These aspects are discussed in detail in Chapter 2. Contents Introduction Gary Evans.
In addition the calculation of total drug exposure in the safety studies is critical to calculating the margin of safety in clinical studies, and by scaling data from different species predictions can be made of the parameters in humans. Pharmacological and toxicological effects are normally only produced by the free drug in the body. Share your thoughts with other customers. Description This stimulating new handbook examines the techniques, methodology and theory of bioanalysis and drug metabolism from the perspective of scientists with extensive professional experience in drug discovery and development.
The importance of the physicochemical properties of drugs to drug metabolism David Spalding. Pharmacokinetic Principles of Dosing Adjustments: There are many in vitro techniques used to investigate the metabolism of compounds.
A Handbook of Bioanalysis and Drug Metabolism
A Chronicle of the National Film Board of Canada from to “has published extensively on the history of media and communications. East Dane Designer Men’s Fashion. The student resources previously accessed via GarlandScience. Enter the email address you signed up with and handbokk email you a reset link. It is especially valuable in lead optimisation for studying the pharmacokinetics of multiple compounds administered simultaneously.
A Handbook of Bioanalysis and Drug Metabolism : Gary Evans :
Add to Wish List. The country you have selected will result in the following: It is important to identify the metabolites and to show that the metabolites which were present in the biownalysis species used in toxicity testing are the same as those buoanalysis in humans. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug—drug interactions. A bioanalytical method consists of two main components: When the potential drug is selected for development, extensive safety and clinical studies are conducted to provide sufficient data for a regulatory submission for registration of a new medicine.
Whilst the pharmacologist or biochemist can develop a screening method for determining which compounds show biological activity against a particular target, these data are of limited value without the knowledge to determine whether the compound can be developed into a commercially viable medicine. Selected pages Title Page Index References Contents Introduction Gary Evans 1 12 The role of BPDM in drug discovery and drug development 2 The importance of the physicochemical properties of drugs to drug metabolism David Spalding 8 22 The physicochemical nature of drug molecules 9 23 The structure of the cell membrane and its implications for drug disposition 10 24 Drug partitioning across membranes 11 25 The ionisation of drugs 13 26 The pH environment of the body and how it affects drug absorption and distribution 17 1O8 References Isotope drug studies in man Graeme Young John Ayrton and Tony Pateman 1 1 2 Which isotope?
In this book this discipline will be referred to as BPDM. The techniques and importance of measuring protein binding are discussed in Chapter 10, illustrated with a case study on a highly protein-bound drug.
Achieving these objectives is not easy, only a small percentage of the chemical compounds synthesised become medicines, most compounds prove unsuitable for reasons of efficacy, potency or toxicity.
The assay does drkg require the high sensitivity which is required in drug development because the concentrations of compound used in the pharmacological screening models and initial in vivo testing are higher than will be encountered in the human studies.
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These in vitro techniques allied to tools provided by molecular biological techniques Chapter 18 permit the scientist to identify the enzymes involved in the metabolism of a drug. Understanding Drug Actions and Reactions. Amazon Rapids Fun stories for kids on the go.